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Anxiety and Dementia: Unraveling the Intriguing Connection

Anxiety, anxious individual fiddling with her fingers and fingernails, picking at her fingernails.

Does Anxiety Increase the Risk of all-Cause Dementia?

In the intricate landscape of health and well-being, the relationship between anxiety and dementia remains a topic of intense investigation. Anxiety, a common mental health condition, has been suggested as a potentially modifiable risk factor for dementia. However, the evidence has been somewhat elusive, with conflicting results across studies. In this blog post, we delve into an updated meta-analysis that sheds light on this intriguing connection.

The Study: Unraveling the Anxiety-Dementia Nexus


The primary objective of this meta-analysis was to explore the association between anxiety and the risk of all-cause dementia. By synthesizing data from prospective population-based studies, the researchers aimed to provide a clearer picture of this relationship.


The researchers meticulously combed through cohort studies listed on PubMed and Web of Science. They focused on studies published from January 2018 to January 2020 that reported risk estimates for the link between anxiety and incident dementia. These newly identified studies were combined with existing data from previously published meta-analyses.

Key Findings

Here’s what the meta-analysis revealed:

  1. Increased Risk: The overall relative risk (RR) of dementia associated with anxiety was 1.24 (95% CI: 1.06–1.46). In other words, individuals with anxiety faced a 24% higher risk of developing dementia compared to those without anxiety.

  2. Population Attributable Fraction (PAF): The PAF, which estimates the proportion of incident dementia cases attributable to anxiety, was 3.9%. This means that nearly 4% of dementia cases could be linked to anxiety.

  3. Prodromal Sign: Interestingly, anxiety with a late-life onset appeared to carry an even higher risk. This suggests that anxiety in older adults might serve as a prodromal sign—an early indicator—of impending dementia.

Implications and Future Directions

The implications of these findings are significant:

  • Clinical Awareness: Healthcare professionals should be attuned to anxiety symptoms in their patients, especially in older adults. Addressing anxiety promptly may contribute to dementia prevention.

  • Research Pathways: While this meta-analysis provides valuable insights, more research is needed to understand the underlying mechanisms. Is anxiety a direct cause of dementia, or does it share common pathways with other risk factors?

Conclusion: A Call for Holistic Care

As we navigate the complexities of mental health and aging, let’s recognize anxiety as more than just a fleeting emotion. It may hold clues to our cognitive well-being. By fostering a holistic approach that considers mental health alongside physical health, we can strive for better outcomes and a dementia-resilient future.

Remember, knowledge empowers us to take proactive steps. Share this information with your loved ones and join the collective effort to promote brain health! 🧠💙

Dr. Dani Ruf, Brain-Based Chiropractor, Meraki Chiropractic PLLC, 08FEB2024


  1. Santabárbara, J., Lipnicki, D. M., Olaya, B., Villagrasa, B., Bueno-Notivol, J., Nuez, L., López-Antón, R., & Gracia-García, P. (2020). Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies. Journal of Clinical Medicine, 9(6), Read the full study here.

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